Paul D van Poelje Selected Research

N,N'- ((5- (2- amino- 5- (2- methylpropyl)- 4- thiazolyl)- 2- furanyl)phosphinylidene)bis(alanine) diethyl ester

1/2011	Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes.
6/2006	Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats.
5/2005	MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.

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Paul D van Poelje Research Topics

Disease

9	Type 2 Diabetes Mellitus (MODY) 01/2011 - 05/2005
3	Hepatitis B 02/2008 - 01/2005
2	Hyperglycemia 01/2011 - 06/2006
2	Hypoglycemia (Reactive Hypoglycemia) 01/2011 - 05/2005
2	Infections 08/2007 - 01/2005
1	Weight Gain 01/2011
1	Insulin Resistance 01/2011
1	Hyperlipidemias (Hyperlipidemia) 12/2010
1	Non-alcoholic Fatty Liver Disease 02/2009
1	Liver Cirrhosis (Hepatic Cirrhosis) 02/2009
1	Metabolic Diseases (Metabolic Disease) 12/2007
1	Body Weight (Weight, Body) 09/2007
1	Hepatocellular Carcinoma (Hepatoma) 02/2005
1	Liver Diseases (Liver Disease) 02/2005
1	Hepatitis C 02/2005

Drug/Important Bio-Agent (IBA)

8	Glucose (Dextrose)FDA LinkGeneric 01/2011 - 05/2005
6	ProdrugsIBA 12/2010 - 01/2005
4	Pharmaceutical PreparationsIBA 12/2010 - 05/2005
3	Fructose-BisphosphataseIBA 01/2011 - 07/2007
3	N,N'- ((5- (2- amino- 5- (2- methylpropyl)- 4- thiazolyl)- 2- furanyl)phosphinylidene)bis(alanine) diethyl esterIBA 01/2011 - 05/2005
2	EnzymesIBA 01/2011 - 12/2007
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2011 - 05/2005
2	2- ((3,5- dimethyl- 4- (4'- hydroxy- 3'- isopropylbenzyl)phenoxy)methyl)- 4- (3- chlorophenyl)- 2- oxido(1,3,2)dioxaphosphonaneIBA 02/2009 - 09/2007
2	Blood Glucose (Blood Sugar)IBA 12/2007 - 07/2007
2	Triglycerides (Triacylglycerol)IBA 09/2007 - 05/2005
2	FructoseIBA 06/2006 - 05/2005
1	Insulin (Novolin)FDA Link 01/2011
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2011
1	LipidsIBA 01/2011
1	Organophosphonates (Phosphonates)IBA 12/2010
1	Transaminases (Aminotransferases)IBA 02/2009
1	Nonesterified Fatty Acids (NEFA)IBA 02/2009
1	LDL CholesterolIBA 02/2009
1	Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA 02/2009
1	Thyroid HormonesIBA 02/2009
1	pradefovirIBA 02/2008
1	adefovir dipivoxil (Hepsera)FDA Link 02/2008
1	adefovirIBA 02/2008
1	Adenosine Monophosphate (AMP)IBA 12/2007
1	CholesterolIBA 09/2007
1	KB 141IBA 09/2007
1	2'-C-methyladenosineIBA 08/2007
1	GlycogenIBA 06/2006
1	NucleosidesIBA 01/2005
1	Lamivudine (Epivir)FDA Link 01/2005
1	Antiviral Agents (Antivirals)IBA 01/2005

Therapy/Procedure

2	Therapeutics 08/2007 - 02/2005
1	Intravenous Administration 01/2010
1	Aftercare (After-Treatment) 02/2009